abstract：:A significant reduction in the incidence of experimental allergic encephalomyelitis (EAE) in SJL/J mice was observed when mice were infected with lactic dehydrogenase virus (LDV) 14 days before, on day 0, or 3 days after immunization with spinal cord homogenate. These results are discussed in terms of the selective in...

journal_title：Journal of neuroimmunology

authors： Inada T,Mims CA

更新日期：1986-03-01 00:00:00

abstract：:DNA synthesis was studied in primary glial cell cultures derived from adult human non-neoplastic and neoplastic brain tissues. Enhanced DNA synthesis occurred in 5/5 non-neoplastic astrocyte, one oligodendroglioma, and 2/5 astrocytoma cultures after exposure to medium containing 1.25-12.5% supernatant fluid (SF) from ...

journal_title：Journal of neuroimmunology

authors： Barna BP,Chou SM,Jacobs B,Ransohoff RM,Hahn JF,Bay JW

更新日期：1985-12-01 00:00:00

abstract：:An electroimmunoblotting technique was used with a monoclonal antibody to myelin basic protein (MBP) to assess demyelination in 3 defined regions of the spinal cord in rats with acute experimental autoimmune encephalomyelitis (EAE). A slight loss in MBP was detected only in the sacrococcygeal region of the spinal cord...

journal_title：Journal of neuroimmunology

authors： Kerlero de Rosbo N,Bernard CC,Simmons RD,Carnegie PR

更新日期：1985-10-01 00:00:00

abstract：:Cell lines of autoimmune T-lymphocytes have been established in several neuroimmunological model diseases and also in a human neurological autoimmune disease, myasthenia gravis. These cell lines generally have the T helper/inducer phenotype and recognize autoantigen in the context of class II histocompatibility antige...

journal_title：Journal of neuroimmunology

authors： Hohlfeld R,Toyka KV

更新日期：1985-08-01 00:00:00

abstract：:Astrocytic cells of unusual aspect can be detected in the cerebellum of normal mice during the first 4 weeks of life. They are visualized with anti-GFAP (glial fibrillary acidic protein), anti-S100 and anti-vimentin immune sera. Their perikaryons, located in the white matter or in the granular layer, extend long proce...

journal_title：Journal of neuroimmunology

authors： Benjelloun-Touimi S,Jacque CM,Derer P,De Vitry F,Maunoury R,Dupouey P

更新日期：1985-07-01 00:00:00

abstract：:Antisera raised to the astrocyte intermediate filament structural protein stained elements in the peripheral nerves of several species. These elements were not associated with myelinated nerve fibers, were more common in splenic and vagus nerves than in the sciatic nerve, and persisted after nerve transection. In teas...

journal_title：Journal of neuroimmunology

authors： Fields KL,Yen SH

更新日期：1985-06-01 00:00:00

abstract：:We compared the distribution of circulating T-cell subsets within 2 weeks of onset of symptoms in 14 patients with acute Guillain-Barré syndrome (GBS) and 37 normal controls. The levels of OKT4+ (putative helper-inducer) cells was definitely abnormal (decreased) in 3/13 tested. The levels of OKT8+ (putative suppressor...

journal_title：Journal of neuroimmunology

authors： Lisak RP,Zweiman B,Guerrero F,Moskovitz AR

更新日期：1985-05-01 00:00:00

abstract：:A technique is described which allows the detection of virus-specific oligoclonal IgG in unconcentrated cerebrospinal fluid (CSF) from patients with virus infections of the central nervous system. CSF is isoelectrically focused in agarose gels and immunoglobulins are blotted to nitrocellulose filters, passively loaded...

journal_title：Journal of neuroimmunology

authors： Dörries R,Ter Meulen V

更新日期：1984-12-01 00:00:00

abstract：:A range of cell-specific markers have been employed with immunocytochemical methods to characterise and quantitate the cell types present in mixed brain cell cultures derived from dissociated 1-2-day post-natal rat cerebral hemispheres and grown in the presence of FCS. Protoplasmic astrocytes (GFAP+, A2B5-) were the m...

journal_title：Journal of neuroimmunology

authors： Walker AG,Chapman J,Bruce CB,Rumsby MG

更新日期：1984-11-01 00:00:00

abstract：:Thymic function in myasthenic patients was examined using two biochemical markers which specifically define a population of cortisone-sensitive cortical thymocytes. The enzymatic activities of terminal deoxynucleotidyl transferase (TdT) and adenosine deaminase (ADA) were determined in 13 samples. High contents of both...

journal_title：Journal of neuroimmunology

authors： Vezzoni P,Fiacchino F,Clerici L,Sghirlanzoni A,Cerrato D,Peluchetti D,Lucchini R,Raineri M,Cornelio F

更新日期：1984-09-01 00:00:00

abstract：:Myasthenia gravis (MG) is a neuromuscular disease thought to have an autoimmune etiology. The acetylcholine receptor has been considered the primary site of antibody binding; however, other muscle components may be involved in the pathogenesis of myasthenia gravis. This study describes a hypertonic sucrose extract of ...

journal_title：Journal of neuroimmunology

authors： Mehl VS,Lang RW

更新日期：1984-08-01 00:00:00

abstract：:A new technique for a conglutinin ELISA using a microtiter plate has been developed for measuring circulating immune complexes. The sensitivity of our system ranges between 0.2 and 3.2 micrograms equivalents of aggregated human IgG. We have applied this system to 21 normal healthy controls and 80 neurological patients...

journal_title：Journal of neuroimmunology

authors： Araga S,Irie H,Takahashi K

更新日期：1984-06-01 00:00:00

abstract：:T-cell subsets in the peripheral blood were analyzed using monoclonal antibodies during the development of experimental allergic neuritis in Lewis rats. Percentages of helper and suppressor cells and ratios of helper/suppressor cells did not exceed normal limits during the development of the disease. ...

journal_title：Journal of neuroimmunology

authors： Feasby TE,Mazaheri R,Hahn AF,Gilbert JJ,Stiller CR,Keown PA

更新日期：1984-06-01 00:00:00

abstract：:The skin response to myelin basic protein (MBP) was studied in chronic relapsing experimental allergic encephalomyelitis (EAE) using strain 13 guinea pigs. The delayed type skin response showed a monophasic curve; it gradually increased after immunization, reached maximum levels around 80 days post-immunization, and d...

journal_title：Journal of neuroimmunology

authors： Tabira T,Itoyama Y,Kuroiwa Y,Kubo C,Nagai Y

更新日期：1983-12-01 00:00:00

abstract：:Lewis rats were treated from day of birth with a rabbit anti-rat IgM antiserum. As adults these animals were found to have no detectable serum IgM and greatly reduced levels of IgG. They failed to respond to the B-cell mitogen LPS, or to make antibodies to sheep red blood cells (SRBC) or myelin basic protein (BP). The...

journal_title：Journal of neuroimmunology

authors： Willenborg DO,Prowse SJ

更新日期：1983-10-01 00:00:00

abstract：:Autoantibodies against pituitary peptides were demonstrated in sera from multiple sclerosis (MS) patients. Ten patients with lupus erythematosus disseminatus (SLE) and 97 healthy blood donors served as controls. The sera were used as primary antibodies in the indirect immuno-enzyme cytochemical (IEC) method, with fixe...

journal_title：Journal of neuroimmunology

authors： Hansen BL,Hansen GN,Hagen C,Brodersen P

更新日期：1983-10-01 00:00:00

abstract：:A monoclonal antibody (7.1B3) has been produced in mice previously immunised with a glycoprotein fraction prepared from human myotube cells grown in tissue culture. The antibody precipitates an antigen complex of four glycoprotein components from detergent extracted human muscle myotube cultures. These are two chains ...

journal_title：Journal of neuroimmunology

authors： Walsh FS,Phillips E,Dhut S,Moore SE

更新日期：1983-08-01 00:00:00

abstract：:A monoclonal antibody, designated C138, was raised against a particulate fraction from young postnatal mouse cerebellum. In sections from adult mouse brain and cerebellum, this antibody stained a sub-population of neurons. Cell bodies of large neurones and fibre tracts were negative in all brain regions examined, wher...

journal_title：Journal of neuroimmunology

authors： Hirsch MR,Langley OK,Ghandour MS,Hirn M,Gombos G,Goridis C

更新日期：1983-06-01 00:00:00

abstract：:A novel brain-specific antigen, called Sy-1, has been identified in whole rat brain hypotonic extracts by means of an antiserum produced in rabbits against the synaptosomal cytosol. Sy-1 is an acidic protein (pI 4.7) present exclusively in a soluble form and it does not carry any sugar moiety. Sy-1 is found only in ra...

journal_title：Journal of neuroimmunology

authors： Gennarini G,Corsi P,Pavia R,Vitiello F,Di Benedetta C

更新日期：1983-04-01 00:00:00

abstract：:Eleven dogs were experimentally infected with canine distemper virus and studied for periods of up to 63 days post-inoculation. The responsiveness of lymphocytes in vitro toward phytohemagglutinin, myelin basic protein and galactocerebroside was tested at regular intervals during the course of infection by means of [3...

journal_title：Journal of neuroimmunology

authors： Cerruti-Sola S,Kristensen F,Vandevelde M,Bichsel P,Kihm U

更新日期：1983-04-01 00:00:00

abstract：:Lewis rats sensitized against peripheral nervous system antigens can be protected against experimental allergic neuritis (EAN) by the intraperitoneal injection of silica quartz dust. Two doses of 200 mg silica given 8 and 11 days post-inoculation (dpi) protected against the development of both clinical and pathologica...

journal_title：Journal of neuroimmunology

authors： Tansey FA,Brosnan CF

更新日期：1982-11-01 00:00:00

abstract：:Serum prostaglandin E (PGE) levels were measured in rats immediately following electrical stimulation of the mesencephalic periaqueductal gray (PAG) region and the nucleus raphe magnus (NRM) and compared to controls. An additional group received aspirin prior to PAG stimulation. A significant increase in serum PGE lev...

journal_title：Journal of neuroimmunology

authors： Rosshirt W,Simon RH,Shaskan EG,Siok C,Dore-Duffy P

更新日期：1982-11-01 00:00:00

abstract：:Virus may be recovered from various areas of the central nervous system (CNS) of mice for as long as 11 days after inoculation of herpes simplex virus type 1 (HSV-1) into the lip. The probability of isolation from any particular region of the CNS seems to be a function of the distance of that area from the root-entry ...

journal_title：Journal of neuroimmunology

authors： Kastrukoff L,Hamada T,Schumacher U,Long C,Doherty PC,Koprowski H

更新日期：1982-06-01 00:00:00

abstract：:The expression of several cell type-specific markers was studied by indirect immunofluorescence in discontinuous BSA gradient fractionated and unfractionated mouse cerebellar cells cultured for 3 days in vitro from embryonic day 13 through postnatal day 9. Cell surface antigen NS-4 and tetanus toxin receptors are pres...

journal_title：Journal of neuroimmunology

authors： Schnitzer J,Schachner M

更新日期：1981-12-01 00:00:00

abstract：:Thirty monoclonal antibodies produced by mouse hybrid myelomas which react with antigens in hamster or mouse nervous system tissues were derived. Using these antibodies as probes with indirect immunofluorescence and immunoperoxidase techniques, we can selectively identify by morphological criteria many of the structur...

journal_title：Journal of neuroimmunology

authors： Franko MC,Masters CL,Gibbs CJ Jr,Gajdusek DC

更新日期：1981-12-01 00:00:00

abstract：:Mice may be protected from the invariably fatal consequences of intracerebral (i.c.) inoculation of A/WSN influnza virus by intravenous injection with 0.5 mg of virus-specific monoclonal anti-hemagglutinin antibody given 2 days after i.c. challenge. The integrity of the blood-cerebrospinal fluid (CSF) barrier in such ...

journal_title：Journal of neuroimmunology

authors： Doherty PC,Gerhard W

更新日期：1981-09-01 00:00:00

abstract：:The relationship of the mouse nervous system specific band 1 protein to the putative high molecular weight component of the Na+ channel was investigated using antibody to band 1. Morphologic differentiation of cultured neuroblastoma cells has been reported to increase the quantity of the putative Na+ channel high mole...

journal_title：Journal of neuroimmunology

authors： Akeson R,Graham K

更新日期：1981-09-01 00:00:00

abstract：:Early diagnosis of multiple sclerosis (MS) may be assisted by tests for the abnormal immune responses of the central nervous system (CNS) including oligoclonal IgG bands in the cerebrospinal fluid (CSF), increased CNS IgG synthesis, increased CNS antibody synthesis against multiple viruses and increased numbers of enl...

journal_title：Journal of neuroimmunology

authors： Iivanainen MV

更新日期：1981-06-01 00:00:00

abstract：:The timing and intensity of the antibody responses to the marker determinants of synthetic peptide S81 and S82 sequences of bovine myelin basic protein (MBP) (residues 68-83 and 65-83, respectively) were studied in 20 Lewis rats and 6 rabbits. All rats immunized with either peptide in CFA responded with antibody devel...

journal_title：Journal of neuroimmunology

authors： Day ED,Hashim GA,Varitek VA Jr,Paterson PY

更新日期：1981-06-01 00:00:00

abstract：:Multinucleate striated contractile fibers which exhibit differentiation markers characteristic of skeletal muscle develop regularly in optic nerve cultured from 10-day-old rats. In identical conditions, muscle fibers arise also from pineal and occasionally from spinal cord, but not from meninges, cerebral blood vessel...

journal_title：Journal of neuroimmunology

authors： Wier ML,Lennon VA

更新日期：1981-03-01 00:00:00

abstract：:Indirect immunofluorescence and cell-type-specific markers were used to determine whether antibodies directed against specific neural cell types were present in patients with Alzheimer's disease (AD), other neurological diseases (OND) and normal controls. Sera and cerebrospinal fluid (CSF) were tested on either frozen...

journal_title：Journal of neuroimmunology

authors： Watts H,Kennedy PG,Thomas M

更新日期：1981-03-01 00:00:00